[et_pb_section fb_built=”1″ _builder_version=”4.22.1″ _module_preset=”default” min_height=”124px” custom_padding=”||0px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”R&D” _builder_version=”4.22.1″ _module_preset=”default” title_font=”Montserrat|700|||||||” title_text_align=”center” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.22.1″ _module_preset=”default” custom_padding=”53px||0px|||” global_colors_info=”{}”][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” custom_margin=”-57px|auto||auto||” custom_padding=”8px||2px|||” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.22.1″ _module_preset=”default” text_font=”Montserrat||||||||” min_height=”52.8px” custom_padding=”1px|||||” global_colors_info=”{}”]<\/p>\n
XS Innovations is currently further developing and testing the prototype. So far, the device prototype has shown to be effective in four studies.\u00a0 Not only has it proven its functionality in initial animal testing but is also undergoing rigorous biological impact assessments.\u00a0<\/p>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.22.1″ _module_preset=”default” min_height=”588.1px” custom_margin=”-45px|||||” global_colors_info=”{}” custom_padding=”||0px|||”][et_pb_row column_structure=”1_3,1_3,1_3″ _builder_version=”4.22.1″ min_height=”541.1px” locked=”off” global_colors_info=”{}” custom_padding=”||23px|||”][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/xsinnovations.rolandberger.amsterdam\/wp-content\/uploads\/2023\/11\/MicrosoftTeams-image-77-scaled.jpg” title_text=”MicrosoftTeams-image (77)” show_bottom_space=”off” force_fullwidth=”on” align_tablet=”center” align_phone=”center” align_last_edited=”on|desktop” _builder_version=”4.22.1″ min_height=”100px” max_height=”1000px” animation_style=”slide” animation_direction=”bottom” animation_delay=”100ms” animation_intensity_slide=”12%” hover_enabled=”0″ border_radii=”|25px|25px||” locked=”off” global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][et_pb_cta title=”Prototype development” button_url=”#” _builder_version=”4.22.1″ header_level=”h3″ header_font=”Montserrat||||||||” header_line_height=”1.5em” body_font=”Montserrat|300|||||||” body_text_align=”center” body_font_size=”15px” body_line_height=”2em” background_color=”rgba(52,139,157,0.14)” custom_button=”on” button_text_size=”14px” button_text_color=”#348b9d” button_bg_color=”rgba(0,0,0,0.05)” button_border_width=”0px” button_border_radius=”100px” button_letter_spacing=”1px” button_font=”Montserrat||||||||” button_use_icon=”off” background_layout=”light” custom_padding=”30px|30px|30px|30px|true|true” animation_direction=”top” border_radii=”|||25px|25px” box_shadow_style=”preset3″ box_shadow_vertical=”30px” box_shadow_blur=”50px” box_shadow_spread=”-30px” box_shadow_color=”rgba(0,0,0,0.1)” button_text_color_hover=”#ffffff” button_bg_color_hover=”#48d14c” locked=”off” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#ffffff” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#348b9d” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” button_bg_enable_color__hover=”on” min_height=”267px”]<\/p>\n
In the prototype development several studies have already been performed, e.g., a cadaveric arm study and two goat studies.<\/p>\n
[\/et_pb_cta][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/xsinnovations.rolandberger.amsterdam\/wp-content\/uploads\/2023\/11\/MicrosoftTeams-image-81.png” show_bottom_space=”off” force_fullwidth=”on” align_tablet=”center” align_phone=”center” align_last_edited=”on|desktop” _builder_version=”4.22.1″ animation_style=”slide” animation_direction=”bottom” animation_delay=”100ms” animation_intensity_slide=”12%” hover_enabled=”0″ border_radii=”|25px|25px||” locked=”off” global_colors_info=”{}” title_text=”MicrosoftTeams-image (81)” sticky_enabled=”0″][\/et_pb_image][et_pb_cta title=”Preclinical” button_url=”#” _builder_version=”4.22.1″ header_level=”h3″ header_font=”Montserrat||||||||” header_line_height=”1.5em” body_font=”Montserrat|300|||||||” body_text_align=”center” body_font_size=”15px” body_line_height=”2em” background_color=”rgba(52,139,157,0.14)” custom_button=”on” button_text_size=”14px” button_text_color=”#348b9d” button_bg_color=”rgba(0,0,0,0.05)” button_border_width=”0px” button_border_radius=”100px” button_letter_spacing=”1px” button_font=”Montserrat||||||||” button_use_icon=”off” background_layout=”light” custom_padding=”30px|30px|30px|30px|true|true” animation_direction=”top” border_radii=”|||25px|25px” box_shadow_style=”preset3″ box_shadow_vertical=”30px” box_shadow_blur=”50px” box_shadow_spread=”-30px” box_shadow_color=”rgba(0,0,0,0.1)” button_text_color_hover=”#ffffff” button_bg_color_hover=”#48d14c” locked=”off” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#ffffff” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#348b9d” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” button_bg_enable_color__hover=”on” min_height=”267px”]<\/p>\n
The preclinical phase entails biological functionality, placement & immobility and longer term biocompatibility testing.<\/p>\n
[\/et_pb_cta][\/et_pb_column][et_pb_column type=”1_3″ _builder_version=”4.16″ custom_padding=”|||” global_colors_info=”{}” custom_padding__hover=”|||”][et_pb_image src=”https:\/\/xsinnovations.rolandberger.amsterdam\/wp-content\/uploads\/2023\/11\/MicrosoftTeams-image-74-scaled.jpg” title_text=”Close up of doctor and patient sitting at the desk near the window in hospital” show_bottom_space=”off” force_fullwidth=”on” align_tablet=”center” align_phone=”center” align_last_edited=”on|desktop” _builder_version=”4.22.1″ animation_style=”slide” animation_direction=”bottom” animation_delay=”200ms” animation_intensity_slide=”12%” hover_enabled=”0″ border_radii=”|25px|25px||” locked=”off” global_colors_info=”{}” sticky_enabled=”0″][\/et_pb_image][et_pb_cta title=”Clinical” button_url=”#” _builder_version=”4.22.1″ header_level=”h3″ header_font=”Montserrat||||||||” header_line_height=”1.5em” body_font=”Montserrat|300|||||||” body_text_align=”center” body_font_size=”15px” body_line_height=”2em” background_color=”rgba(52,139,157,0.14)” custom_button=”on” button_text_size=”14px” button_text_color=”#348b9d” button_bg_color=”rgba(0,0,0,0.05)” button_border_width=”0px” button_border_radius=”100px” button_letter_spacing=”1px” button_font=”Montserrat||||||||” button_use_icon=”off” background_layout=”light” max_width=”100%” min_height=”267px” custom_padding=”30px|30px|30px|30px|true|true” animation_direction=”top” border_radii=”|||25px|25px” box_shadow_style=”preset3″ box_shadow_vertical=”30px” box_shadow_blur=”50px” box_shadow_spread=”-30px” box_shadow_color=”rgba(0,0,0,0.1)” button_text_color_hover=”#ffffff” button_bg_color_hover=”#48d14c” locked=”off” global_colors_info=”{}” button_text_size__hover_enabled=”off” button_one_text_size__hover_enabled=”off” button_two_text_size__hover_enabled=”off” button_text_color__hover_enabled=”on” button_text_color__hover=”#ffffff” button_one_text_color__hover_enabled=”off” button_two_text_color__hover_enabled=”off” button_border_width__hover_enabled=”off” button_one_border_width__hover_enabled=”off” button_two_border_width__hover_enabled=”off” button_border_color__hover_enabled=”off” button_one_border_color__hover_enabled=”off” button_two_border_color__hover_enabled=”off” button_border_radius__hover_enabled=”off” button_one_border_radius__hover_enabled=”off” button_two_border_radius__hover_enabled=”off” button_letter_spacing__hover_enabled=”off” button_one_letter_spacing__hover_enabled=”off” button_two_letter_spacing__hover_enabled=”off” button_bg_color__hover_enabled=”on|hover” button_bg_color__hover=”#348b9d” button_one_bg_color__hover_enabled=”off” button_two_bg_color__hover_enabled=”off” button_bg_enable_color__hover=”on” custom_margin=”||-14px|||”]<\/p>\n
In the clinical phase XS Innovations will test and evaluate the effects of the Dynamic AVF on humans.<\/p>\n
[\/et_pb_cta][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.22.1″ _module_preset=”default” custom_padding=”||0px|||” global_colors_info=”{}” min_height=”144px”][et_pb_row _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_column type=”4_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_heading title=”Prototype development” _builder_version=”4.22.1″ _module_preset=”default” title_font=”Montserrat|700|||||||” title_text_align=”center” global_colors_info=”{}”][\/et_pb_heading][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.22.1″ _module_preset=”default” background_color=”rgba(52,139,157,0.14)” min_height=”100px” height=”174px” global_colors_info=”{}”][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.22.1″ _module_preset=”default” max_width=”2016px” min_height=”193.7px” custom_padding=”||4px|||” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/xsinnovations.rolandberger.amsterdam\/wp-content\/uploads\/2023\/11\/study-1-2.jpg” title_text=”study 1-2″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/xsinnovations.rolandberger.amsterdam\/wp-content\/uploads\/2023\/11\/Study-2-In-vitro.png” title_text=”Study 2 – In vitro” _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/xsinnovations.rolandberger.amsterdam\/wp-content\/uploads\/2023\/11\/Study-3-Goat.png” title_text=”Study 3 – Goat” _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_image src=”https:\/\/xsinnovations.rolandberger.amsterdam\/wp-content\/uploads\/2023\/11\/Study-3-Goat.png” title_text=”Study 3 – Goat” _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][\/et_pb_image][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”4.22.1″ _module_preset=”default” background_color=”rgba(52,139,157,0.14)” min_height=”438.9px” custom_padding=”||12px|||” locked=”off” global_colors_info=”{}”][et_pb_row column_structure=”1_4,1_4,1_4,1_4″ _builder_version=”4.22.1″ _module_preset=”default” background_color=”RGBA(255,255,255,0)” max_width=”2016px” min_height=”334px” custom_padding=”||8px|||” global_colors_info=”{}”][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Cadaveric arm study” position=”December 2021″ _builder_version=”4.22.1″ _module_preset=”default” header_font=”Montserrat||||||||” body_font=”Montserrat||||||||” custom_padding=”|0px||||” border_color_all_image=”#FFFFFF” global_colors_info=”{}”]<\/p>\n
XSI performed a study on human cadaveric arm to verify the implantation method and dimensions of the device ex vivo. The mock-up fits easily in cadaveric human arm (BMI and height considered average), could be placed and arm could be closed. Moving arm did not result in rupture of anastomotic sutures.<\/p>\n
[\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”In vitro mechanical characterisation” position=”January 2022″ _builder_version=”4.22.1″ _module_preset=”default” header_font=”Montserrat||||||||” body_font=”Montserrat||||||||” min_height=”270px” custom_padding=”0px|2px||0px||” border_color_all_image=”#FFFFFF” locked=”off” global_colors_info=”{}”]<\/p>\n
In January 2022, a mechanical characterization in a benchtop setting was performed. T<\/span>echnical requirements before implantation into animal model, such as non-invasive control of pressurized graft up to skin with a thickness of 5 mm, was determined to be possible.<\/span><\/p>\n [\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Goat study 1″ position=”February 2022″ _builder_version=”4.22.1″ _module_preset=”default” header_font=”Montserrat||||||||” body_font=”Montserrat||||||||” locked=”off” global_colors_info=”{}”]<\/p>\n The first goat study proved the possibility of implantation, non-invasively controlled flow in an acute setting and the feasibility of an actuation method.<\/span><\/p>\n [\/et_pb_team_member][\/et_pb_column][et_pb_column type=”1_4″ _builder_version=”4.22.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_team_member name=”Goat study 2″ position=”December 2022″ _builder_version=”4.22.1″ _module_preset=”default” header_font=”Montserrat||||||||” body_font=”Montserrat||||||||” locked=”off” global_colors_info=”{}”]<\/p>\n The second goat study focused on functionality testing. Closing the AVF normalizes arterial flow and the device appears to be functional after explantation.<\/p>\n [\/et_pb_team_member][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" XS Innovations is currently further developing and testing the prototype. So far, the device prototype has shown to be effective in four studies.\u00a0 Not only has it proven its functionality in initial animal testing but is also undergoing rigorous biological impact assessments.\u00a0In the prototype development several studies have already been performed, e.g., a cadaveric arm […]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","footnotes":""},"class_list":["post-133","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/xsinnovations.rolandberger.amsterdam\/index.php?rest_route=\/wp\/v2\/pages\/133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/xsinnovations.rolandberger.amsterdam\/index.php?rest_route=\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/xsinnovations.rolandberger.amsterdam\/index.php?rest_route=\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/xsinnovations.rolandberger.amsterdam\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/xsinnovations.rolandberger.amsterdam\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=133"}],"version-history":[{"count":15,"href":"https:\/\/xsinnovations.rolandberger.amsterdam\/index.php?rest_route=\/wp\/v2\/pages\/133\/revisions"}],"predecessor-version":[{"id":659,"href":"https:\/\/xsinnovations.rolandberger.amsterdam\/index.php?rest_route=\/wp\/v2\/pages\/133\/revisions\/659"}],"wp:attachment":[{"href":"https:\/\/xsinnovations.rolandberger.amsterdam\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}